Key result
Concomitant cardiac amyloidosis in aortic stenosis is linked to ~160% higher all-cause mortality.
Why the study?
Cardiac amyloidosis remains underdiagnosed in patients with aortic stenosis, and optimal screening, diagnostic, and therapeutic strategies for concomitant AS and CA are still evolving.
Relative Risk: 2.6 (95% CI 1.48–4.57)
p-value: p=0.0009
Concomitant cardiac amyloidosis is common in elderly patients with severe aortic stenosis and significantly increases mortality, highlighting the need for systematic multimodality screening.
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May warrant amyloid evaluation in aortic stenosis; leaves open whether screening or therapy improves outcomes.
Edel Alberto Hernández González (2026) conducted a review in Aortic stenosis and cardiac amyloidosis. Concomitant cardiac amyloidosis vs. Aortic stenosis without cardiac amyloidosis was evaluated on All-cause mortality (RR 2.60, 95% CI 1.48-4.57, p=0.0009). The presence of concomitant cardiac amyloidosis in patients with aortic stenosis is associated with a significantly higher risk of all-cause mortality (RR 2.60) compared to aortic stenosis alone.
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