Changes in SGLT2i and GLP-1RA real-world initiator profiles following cardiovascular outcome trials: A Danish nationwide population-based study

Figures

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  Fig 1. Quarterly number of initiators of DPP-4i, GLP-1RA, and SGLT2i in Denmark, 2014–2017. DPP-4i: dipeptidyl peptidase-4 inhibitor; GLP-1RA: glucagon-like peptide-1 receptor agonists; SGLT2i: sodium-glucose cotransporter 2 inhibitors; TECOS: Sitagliptin (DPP-4i) showed non-inferiority to placebo [35]; Lira obesity label: Liraglutide 3 mg launched as treatment for obesity; EMPA-REG OUTCOME: empagliflozin showed CV and CV/all-cause mortality benefits [10], LEADER: liraglutide showed CV and CV/all-cause mortality benefits [12]; CANVAS: canagliflozin showed CV benefits [11].

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  Fig 2. Time trends in proportions using various baseline glucose-lowering drug regimens at the time of initiation of DPP-4i, GLP-1RA, and SGLT2i, respectively. Graphs show the proportion of patients who–at the time of their first initiation of either DPP-4i, GLP-1RA, or SGLT2i –are on no other GLD treatment (red graph), on another GLD monotherapy (green graph), on dual GLD therapy (blue graph), or on triple GLD therapy (purple graph). DPP-4i: dipeptidyl peptidase-4 inhibitor; GLP-1RA: glucagon-like peptide-1 receptor agonists; SGLT2i: sodium-glucose cotransporter 2 inhibitors; TECOS: Sitagliptin (DPP-4i) showed non-inferiority to placebo [35]; Lira obesity label: Liraglutide 3 mg launched as treatment for obesity; EMPA-REG OUTCOME: empagliflozin showed CV and CV/all-cause mortality benefits [10], LEADER: liraglutide showed CV and CV/all-cause mortality benefits [12]; CANVAS: canagliflozin showed CV benefits [11].

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  Fig 3. Time trends in proportions with established atherosclerotic cardiovascular disease (ASCVD) or hospital-diagnosed obesity at baseline. Obesity: used hospital inpatient and outpatient contacts. ASCVD: atherosclerotic cardiovascular disease; DPP-4i: dipeptidyl peptidase-4 inhibitor; GLP-1RA: glucagon-like peptide-1 receptor agonists; SGLT2i: sodium-glucose cotransporter 2 inhibitors; TECOS: Sitagliptin (DPP-4i) showed non-inferiority to placebo [35]; Lira obesity label: Liraglutide 3 mg launched as treatment for obesity; EMPA-REG OUTCOME: empagliflozin showed CV and CV/all-cause mortality benefits [10], LEADER: liraglutide showed CV and CV/all-cause mortality benefits [12]; CANVAS: canagliflozin showed CV benefits [11].

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  Fig 4. Time trends in patient proportions with acute myocardial infarction (AMI), heart failure (HF), or stroke at baseline. AMI: acute myocardial infarction; HF: heart failure; DPP-4i: dipeptidyl peptidase-4 inhibitor; GLP-1RA: glucagon-like peptide-1 receptor agonists; SGLT2i: sodium-glucose cotransporter 2 inhibitors; TECOS: Sitagliptin (DPP-4i) showed non-inferiority to placebo [35]; Lira obesity label: Liraglutide 3 mg launched as treatment for obesity; EMPA-REG OUTCOME: empagliflozin showed CV and CV/all-cause mortality benefits [10], LEADER: liraglutide showed CV and CV/all-cause mortality benefits [12]; CANVAS: canagliflozin showed CV benefits [11].