What question did this study set out to answer?

This research aims to evaluate the impact of premature atrial depolarization on the automaticity of the sinus node.

June 1, 1976CirculationOpen Access

The effect of premature atrial depolarization on sinus node automaticity in man.

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Why the study?

Does premature atrial depolarization affect sinus node automaticity in patients?

Population

71 patients

Comparison

Programmed premature atrial stimulation during… vs Spontaneous cycle length

Design

Cohort

Authors

GBG BreithardtUniversity Hospital Münster LSL SeipelBernstein Center for Computational Neuroscience Tübingen

Discussion

Member takes

Implication

May mildly depress sinus node automaticity after reset; leaves open whether extrastimulus SACT calculations overestimate true values.

Key Points

This research aims to evaluate the impact of premature atrial depolarization on the automaticity of the sinus node.
Compared post-return cycle lengths to spontaneous cycle lengths in 71 patients using programmed atrial stimulation.
Grouped patients based on clinical diagnosis and calculated sino-atrial conduction time (SACT).
Measured post-return cycle changes at varying coupling intervals.
At long coupling intervals, the post-return cycles were prolonged by less than 8.4 msec, indicating minimal effect.
Test stimuli that reset the sinus node resulted in significant prolongation of post-return cycles by 20 to 30 msec.
Prolongation of post-return cycles was inconsistent across individual cases, with some showing no significant change.

Structured PICO

Does premature atrial depolarization affect sinus node automaticity in patients?

Population

71 patients

Intervention

Programmed premature atrial stimulation during spontaneous sinus rhythm

Comparator

Spontaneous cycle length

Outcome

Length of the post-return cycles compared to the spontaneous cycle lengthsurrogate

Premature depolarization of the sinus node may have a small depressant effect on its automaticity, suggesting that calculating SACT using the extrastimulus technique may overestimate true SACT.

Cite This Study

Breithardt et al. (1976) studied this question.

synapsesocial.com/papers/6a71f049a7fbea1e44088bba https://doi.org/10.1161/01.cir.53.6.920

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The effect of premature atrial depolarization on sinus node automaticity in man.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

The effect of premature atrial depolarization on sinus node automaticity in man.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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