Why the study?
Does clopidogrel plus aspirin reduce cardiovascular events in people at high risk of atherothrombotic disease without a coronary stent compared to aspirin alone?
Population
15 RCTs pooling 33,970 people with coronary disease, ischaemic cerebrovascular disease, peripheral arterial…
Comparison
Clopidogrel plus aspirin for over 30 days vs Aspirin plus placebo or aspirin alone
Design
Meta-analysis
Follow-up
median 12 months
Authors
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Reduces MI and ischemic stroke but increases major bleeding without mortality benefit; does not support routine addition and leaves open targeted subgroup trials.
Does clopidogrel plus aspirin reduce cardiovascular events in people at high risk of atherothrombotic disease without a coronary stent compared to aspirin alone?
In patients at high cardiovascular risk without a coronary stent, adding clopidogrel to aspirin reduces myocardial infarction and ischaemic stroke but significantly increases major and minor bleeding without improving survival.
Squizzato et al. (2017) studied this question.
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