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January 1, 1957Experimental Biology and Medicine

Isolation of Intranuclear Inclusion Producing Agents from Infants with Illnesses Resembling Cytomegalic Inclusion Disease.

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Population

3 infants with illnesses resembling cytomegalic inclusion disease.

Design

Case_series

Authors

TWThomas H. WellerLeibniz Institute of European HistoryJMJ. C. MacAuleyJCJohn M. CraigNational Institutes of Health

Discussion

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Overview

May support viral etiology in cytomegalic inclusion disease-like illness; hypothesis-generating and requires confirmation in larger cohorts.

Structured PICO

P
Population
3 infants with illnesses resembling cytomegalic inclusion disease (presenting with features such as jaundice, hepatosplenomegaly, microcephaly, cerebral calcification, and chorioretinitis).
I
Intervention
Virus isolation from liver biopsy and urine, and propagation in human fibroblasts.
O
Outcome
Isolation and in vitro propagation of intranuclear inclusion producing agents (viruses).

The study reports the successful isolation and in vitro propagation of viruses associated with cytomegalic inclusion disease from affected infants.

Cite This Study

Weller et al. (1957) studied this question.

synapsesocial.com/papers/6a71f0b0f44fa9f079df987ahttps://doi.org/10.3181/00379727-94-22841
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1CONGENITAL AND ACQUIRED CYTOMEGALOVIRUS INFECTIONS Virological and Clinical Studies on a Swedish Infant Population1978 · 39 citations
  2. 2Congenital and acquired forms of cytomegalovirus infection in infants2024
  3. 3Fatal congenital cytomegalovirus infection following recurrent maternal infection after a 7-year interval.2007 · 6 citations
  4. 4GENERALIZED CYTOMEGALIC INCLUSION-BODY DISEASE ASSOCIATED WITH PNEUMOCYSTIS PNEUMONIA IN ADULTS1960 · 94 citations
  5. 5Severe Cholestatic Hepatitis in Retroviral Infection2024