Why the study?
Does 244 protecting virus protect mice against lethal influenza A virus challenge?
Population
Mice challenged with lethal doses of influenza A viruses (H1N1, H2N2, H3N2, and H3N8)
Design
Preclinical
Authors
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Offers preclinical protection in mice; leaves open human translation and trials.
Does 244 protecting virus protect mice against lethal influenza A virus challenge?
A novel defective influenza virus RNA (244 RNA) provides effective prophylactic and therapeutic protection against lethal influenza A challenges in a mouse model.
Dimmock et al. (2008) studied this question.
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