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June 15, 2007The Primary Care Companion to The Journal of Clinical PsychiatryOpen Access

Massive Epistaxis and Subconjunctival Hemorrhage Due to Combination of Paroxetine and Limaprost Alfadex

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Population

1 patient, 36-year-old woman of Korean descent with a 16-year history of schizoaffective disorder admitted…

Design

Case_report

Authors

NSNobuhiro SugiyamaDSDaimei SasayamaNANaoji Amano

Discussion

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Overview

May prompt monitoring for hypersalivation with quetiapine; single case leaves open prevalence and causality.

Structured PICO

P
Population
1 patient (n=1), 36-year-old woman of Korean descent with a 16-year history of schizoaffective disorder admitted with a relapse of mania with psychosis.
I
Intervention
Quetiapine 25 mg twice daily, increased to 50 mg twice daily
O
Outcome
Hypersalivationsafety

Quetiapine may induce hypersalivation, potentially due to its alpha-2 adrenergic receptor blockade.

Limitations

  • Single case report
  • Further study is needed to draw definite conclusions

Cite This Study

Sugiyama et al. (2007) studied this question.

synapsesocial.com/papers/6a71f443c1a24a6142dbc5f8https://doi.org/10.4088/pcc.v09n0311j
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