Why the study?
Does quetiapine improve symptoms in schizophrenic patients with partial response to conventional antipsychotics compared to haloperidol?
Population
288 schizophrenic patients with a history of partial response to conventional antipsychotics and displayed a…
Comparison
Quetiapine 600 mg/day for 8 weeks vs Haloperidol 20 mg/day for 8 weeks
Design
RCT, double-blind
Follow-up
8 weeks
Authors
Loading...
Quetiapine failed to meet the primary PANSS endpoint versus haloperidol; leaves open its role in partial responders pending confirmatory trials.
Does quetiapine improve symptoms in schizophrenic patients with partial response to conventional antipsychotics compared to haloperidol?
Quetiapine may offer a better tolerability profile and higher clinical response rate than haloperidol in schizophrenic patients with a history of partial response to conventional antipsychotics.
Emsley et al. (2000) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: