April 1, 2002Journal of Clinical Psychopharmacology
Effect of Fluoxetine and Imipramine on the Pharmacokinetics and Tolerability of the Antipsychotic Quetiapine
Why the study?
Does fluoxetine or imipramine alter the pharmacokinetics and tolerability of quetiapine in patients with schizophrenia, schizoaffective disorder, or bipolar disorder?
Population
26 patients with schizophrenia, schizoaffective disorder, or bipolar disorder
Comparison
Fluoxetine or imipramine added to quetiapine for… vs Quetiapine alone (300 mg twice daily)
Design
RCT, randomized, open-label
Follow-up
8 days
Authors
Discussion
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Implication
Supports coadministration without dose adjustment; extends pharmacokinetic safety data for these combinations in psychiatric patients.
Structured PICO
Does fluoxetine or imipramine alter the pharmacokinetics and tolerability of quetiapine in patients with schizophrenia, schizoaffective disorder, or bipolar disorder?
P
Population
26 patients with schizophrenia, schizoaffective disorder, or bipolar disorder
I
Intervention
Fluoxetine (60 mg daily) or imipramine (75 mg twice daily) added to quetiapine (300 mg twice daily) for 8 days
C
Comparator
Quetiapine alone (300 mg twice daily)
O
Outcome
Pharmacokinetic analysis of quetiapine, Udvalg for kliniske undersøgelser (UKU) Side Effect Rating Scale, and safety evaluationssurrogate
Combination therapy of quetiapine with fluoxetine or imipramine has minimal effects on quetiapine pharmacokinetics and is generally well tolerated.
Cite This Study
Potkin et al. (2002) studied this question.