Why the study?
Does decreased ventricular filling in utero reduce left ventricular growth and lead to a hypoplastic phenotype in a computational model of the human fetal heart?
Population
Computational finite element model of human fetal left ventricle, calibrated using median dimensions of 14…
Comparison
Simulated decreased ventricular filling volume… vs Simulated normal ventricular filling volume at…
Design
Preclinical, retrospective blinded case studies
Follow-up
mid-gestation to birth (40 weeks)
Authors
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Hypothesis-generating for fetal LV filling in HLHS; prospective validation needed before prognostic use.
Does decreased ventricular filling in utero reduce left ventricular growth and lead to a hypoplastic phenotype in a computational model of the human fetal heart?
A computational model demonstrates that reduced ventricular filling and altered shape at mid-gestation can predict reduced left ventricular growth and a hypoplastic phenotype at birth.
Dewan et al. (2017) studied this question.
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