Why the study?
Does distention of the immature left ventricle trigger the development of endocardial fibroelastosis in a rat model?
Population
Neonatal donor rat hearts heterotopically transplanted into recipient adult rats
Comparison
Creation of aortic regurgitation in the donor… vs Transplanted donor hearts with a competent…
Design
Preclinical
Follow-up
2 weeks
Authors
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LV distention induces EFE in immature rat hearts; leaves open human HLHS relevance and requires prospective validation.
Does distention of the immature left ventricle trigger the development of endocardial fibroelastosis in a rat model?
Distention of the immature left ventricle combined with stagnant flow triggers endocardial fibroelastosis in a novel rat model, providing a tool to study evolving hypoplastic left heart syndrome.
Shimada et al. (2015) studied this question.
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