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January 1, 2015BioMed Research InternationalOpen Access

Distention of the Immature Left Ventricle Triggers Development of Endocardial Fibroelastosis: An Animal Model of Endocardial Fibroelastosis Introducing Morphopathological Features of Evolving Fetal Hypoplastic Left Heart Syndrome

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Why the study?

Does distention of the immature left ventricle trigger the development of endocardial fibroelastosis in a rat model?

Population

Neonatal donor rat hearts heterotopically transplanted into recipient adult rats

Comparison

Creation of aortic regurgitation in the donor… vs Transplanted donor hearts with a competent…

Design

Preclinical

Follow-up

2 weeks

Authors

SSShogo ShimadaKitasato UniversityCRChristian RoblesWake Forest UniversityBIBen IlligensIcahn School of Medicine at Mount Sinai

Discussion

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Implication

LV distention induces EFE in immature rat hearts; leaves open human HLHS relevance and requires prospective validation.

Structured PICO

Does distention of the immature left ventricle trigger the development of endocardial fibroelastosis in a rat model?

P
Population
Neonatal donor rat hearts heterotopically transplanted into recipient adult rats
I
Intervention
Creation of aortic regurgitation (AR) in the donor heart to induce LV distention and stagnant flow
C
Comparator
Transplanted donor hearts with a competent aortic valve (unloaded LVs)
O
Outcome
Development of endocardial fibroelastosis (EFE) and LV morphologysurrogate

Distention of the immature left ventricle combined with stagnant flow triggers endocardial fibroelastosis in a novel rat model, providing a tool to study evolving hypoplastic left heart syndrome.

Cite This Study

Shimada et al. (2015) studied this question.

synapsesocial.com/papers/6a71f7485d37378ac1deeef9https://doi.org/10.1155/2015/462469
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Left ventricular dysfunction in the fetus: relation to aortic valve anomalies and endocardial fibroelastosis.1991 · 133 citations
  2. 2The Diagnosis of Primary Endocardial Fibroelastosis1964 · 53 citations
  3. 3Experimental aortic stenosis in fetal lambs.1980 · 8 citations
  4. 4Benefits of long-term β-blockade in experimental chronic aortic regurgitation2008 · 44 citations
  5. 5Staged Left Ventricular Recruitment After Single-Ventricle Palliation in Patients With Borderline Left Heart Hypoplasia2012 · 172 citations