Investigation antimicrobial interaction of arbutin and antibiotics of different groups against gram-negative bacteria strains

Actuality.The basic therapy against microbial infections is application antibiotics.However, overuse of antibiotics has become the major factor for the emergence and dissemination of multi-drug resistant strains.The aim of the study was investigate in vitro and in silico antimicrobial interaction of arbutin and antibiotics of different group against bacteria strains E. coli, P. aeruginosa, P. vulgaris.Materials and methods.The molecular docking was performed using AutoDockTools 1.5.6;antimicrobial effects were evaluated by the well method.