October 29, 2013EndocrinologyOpen Access

Aldosterone Secretagogues Increase Adrenal Blood Flow in Male Rats

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Population

Anesthetized male Sprague-Dawley rats

Design

Preclinical

Authors

IAIshrath AnsurudeenKarolinska Institutet PKPhillip G. KopfMidwestern University KGKathryn M. GauthierMedical College of Wisconsin

Discussion

Member takes

Implication

Findings in rats warrant no change in clinical practice; leaves open cytochrome P450 metabolite role in human adrenal blood flow.

Structured PICO

Population

Anesthetized male Sprague-Dawley rats

Intervention

Bolus injections of Angiotensin II (0.01-1000 ng/kg), ACTH (0.1-1000 ng/kg), endothelin-1 (1-1000 ng/kg), sodium nitroprusside (1 and 10 μg/kg), and miconazole (2 mg/kg)

Outcome

Adrenal blood flow (ABF) and mean arterial pressure (MAP)surrogate

Angiotensin II and ACTH increase adrenal blood flow in rats via a cytochrome P450 metabolite-mediated mechanism.

Cite This Study

Ansurudeen et al. (2013) studied this question.

synapsesocial.com/papers/6a71fb02a7fbea1e44088dd6 https://doi.org/10.1210/en.2013-1532

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Aldosterone Secretagogues Increase Adrenal Blood Flow in Male Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Aldosterone Secretagogues Increase Adrenal Blood Flow in Male Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider