Key result
Angiotensin II stimulates adrenal cortical arterial dilation through endothelial cell AT2 receptor activation and NO release, and AT1 receptor-dependent constriction.
Population
Cannulated bovine adrenal cortical arteries
Comparison
Angiotensin II (10(-13) to 10(-8) mol/liter) vs Endothelial cell removal, AT1 receptor…
Design
Preclinical
Authors
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Animal findings on Ang II dual effects in adrenal arterioles leave open translation to human adrenal perfusion or hypertension.
Angiotensin II exerts a dual effect on adrenal cortical arterioles, causing AT2-mediated, NO-dependent dilation at low concentrations and AT1-mediated constriction at high concentrations.
Gauthier et al. (2005) studied this question. Angiotensin II was evaluated on concentration-diameter responses. Angiotensin II stimulates adrenal cortical arterial dilation through endothelial cell AT2 receptor activation and NO release, and AT1 receptor-dependent constriction.
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