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Case report reveals normal chromosome complements across bone marrow and blood in erythroleukaemia, indicating that malignant cells can develop without gross chromosomal abnormalities.
A case of DiGuglielmo syndrome is reported in which chromosome studies on bone marrow, peripheral blood cultures stimulated with phytohaemagglutinin, and peripheral blood cultures without phytohaemagglutinin stimulation all revealed normal chromosome complements from the standpoint of chromosome morphology, aneuploidy, polyploidy, and chromosome breakage. Since the peripheral blood cells without phytohaemagglutinin stimulation should represent the malignant cells, this would indicate that the malignant cells do occur without chromosome abnormalities.
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Nichols et al. (1970) studied this question.
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