What question did this study set out to answer?

To determine the relationship among capsular serotypes, penicillin susceptibility, and intraperitoneal virulence of clinical Streptococcus pneumoniae strains in mice.

June 1, 2000Antimicrobial Agents and ChemotherapyOpen Access

Relationship between Capsular Type, Penicillin Susceptibility, and Virulence of Human Streptococcus pneumoniae Isolates in Mice

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Authors

EAE. Azoulay-DupuisUniversité Claude Bernard Lyon 1 VRVéronique RieuxAgence Nationale de Recherches sur le Sida et les Hépatites Virales MMMartine Muffat‐JolyInserm

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Implication

Experimental animal study uncovers an inverse relationship between penicillin resistance and virulence in mice, suggesting resistance mechanisms may reduce bacterial lethality.

Key Points

To determine the relationship among capsular serotypes, penicillin susceptibility, and intraperitoneal virulence of clinical Streptococcus pneumoniae strains in mice.
Assessed 122 clinical S. pneumoniae isolates representing 24 serotypes for penicillin susceptibility and peritoneal virulence in Swiss mice.
Classified isolates into four distinct groups according to their capsular serotypes and pathogenic profiles.
All 32 virulent isolates were susceptible to penicillin, whereas all 41 isolates with diminished susceptibility or resistance were completely avirulent.
Virulence rates varied significantly by serogroup, occurring in 81.3% of serotypes 1, 3, and 4 strains versus 34.4% in serotype 6 strains (P=0.002) and 0% in serotypes 9, 14, 19, and 23 strains.

Cite This Study

Azoulay-Dupuis et al. (2000) studied this question.

synapsesocial.com/papers/6a71fbd822b3175134db6c47 https://doi.org/10.1128/aac.44.6.1575-1577.2000

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Implication

Experimental animal study uncovers an inverse relationship between penicillin resistance and virulence in mice, suggesting resistance mechanisms may reduce bacterial lethality.

Relationship between Capsular Type, Penicillin Susceptibility, and Virulence of Human Streptococcus pneumoniae Isolates in Mice

Discussion

Member takes

Implication

Key Points

Cite This Study

Relationship between Capsular Type, Penicillin Susceptibility, and Virulence of Human Streptococcus pneumoniae Isolates in Mice

Discussion

Member takes

Implication

Key Points

Cite This Study

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