What question did this study set out to answer?

To evaluate the in vivo analgesic and anti-inflammatory activities of aqueous extracts of Rosmarinus officinalis leaves and stems, pure rosmarinic acid, and an acetyl ester derivative of rosmarinic acid.

June 5, 2013Pharmaceutical BiologyOpen Access

In vivoanalgesic and anti-inflammatory activities ofRosmarinus officinalisaqueous extracts, rosmarinic acid and its acetyl ester derivative

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Authors

RLRodrigo LucariniUniversidade Vale do Rio Verde WBWagner Antônio BernardesCentro Universitário do Cerrado Patrocínio DFDaniele S. Ferreira

Discussion

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Overview

Preclinical study demonstrates analgesic and anti-inflammatory efficacy of an acetylated rosmarinic acid derivative in rodent models, indicating potential as a therapeutic lead.

Key Points

To evaluate the in vivo analgesic and anti-inflammatory activities of aqueous extracts of Rosmarinus officinalis leaves and stems, pure rosmarinic acid, and an acetyl ester derivative of rosmarinic acid.
Tested oral aqueous leaf and stem extracts at 100, 200, and 400 mg/kg, and isolated rosmarinic acid and its acetyl ester derivative at 10, 20, and 40 mg/kg in animal models.
Assessed analgesic activity via abdominal constriction and formalin tests, and evaluated anti-inflammatory activity using carrageenin-induced paw edema in rats.
Aqueous leaf extracts, stem extracts, and unmodified rosmarinic acid showed no significant analgesic activity at any tested dose in the abdominal constriction test.
The acetyl ester derivative of rosmarinic acid exhibited significant analgesic activity in the abdominal constriction test and significantly reduced paw licking during the second phase of the formalin test.
The acetyl ester derivative produced significant anti-inflammatory effects across all tested doses (10, 20, and 40 mg/kg) in the carrageenin-induced paw edema assay.

Cite This Study

Lucarini et al. (2013) studied this question.

synapsesocial.com/papers/6a71fd47ac440176ef2a7483 https://doi.org/10.3109/13880209.2013.776613

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June 5, 2013Pharmaceutical BiologyOpen Access

In vivoanalgesic and anti-inflammatory activities ofRosmarinus officinalisaqueous extracts, rosmarinic acid and its acetyl ester derivative

View Full Paper

Ask AI

Bookmark

Authors

RLRodrigo LucariniUniversidade Vale do Rio Verde WBWagner Antônio BernardesCentro Universitário do Cerrado Patrocínio DFDaniele S. Ferreira

Discussion

Member takes

Overview

Preclinical study demonstrates analgesic and anti-inflammatory efficacy of an acetylated rosmarinic acid derivative in rodent models, indicating potential as a therapeutic lead.

Key Points

To evaluate the in vivo analgesic and anti-inflammatory activities of aqueous extracts of Rosmarinus officinalis leaves and stems, pure rosmarinic acid, and an acetyl ester derivative of rosmarinic acid.
Tested oral aqueous leaf and stem extracts at 100, 200, and 400 mg/kg, and isolated rosmarinic acid and its acetyl ester derivative at 10, 20, and 40 mg/kg in animal models.
Assessed analgesic activity via abdominal constriction and formalin tests, and evaluated anti-inflammatory activity using carrageenin-induced paw edema in rats.
Aqueous leaf extracts, stem extracts, and unmodified rosmarinic acid showed no significant analgesic activity at any tested dose in the abdominal constriction test.
The acetyl ester derivative of rosmarinic acid exhibited significant analgesic activity in the abdominal constriction test and significantly reduced paw licking during the second phase of the formalin test.
The acetyl ester derivative produced significant anti-inflammatory effects across all tested doses (10, 20, and 40 mg/kg) in the carrageenin-induced paw edema assay.

Cite This Study

Lucarini et al. (2013) studied this question.

synapsesocial.com/papers/6a71fd47ac440176ef2a7483 https://doi.org/10.3109/13880209.2013.776613

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