What question did this study set out to answer?

To examine temporal alterations in cerebrospinal fluid levels of Alzheimer's disease biomarkers—tau, amyloid beta(1-42), and apolipoprotein E—following acute ischemic stroke.

October 1, 2000Journal of Alzheimer s Disease

Cerebrospinal Fluid Markers for Alzheimer's Disease Evaluated after Acute Ischemic Stroke

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To examine temporal alterations in cerebrospinal fluid levels of Alzheimer's disease biomarkers—tau, amyloid beta(1-42), and apolipoprotein E—following acute ischemic stroke.
Evaluated serial cerebrospinal fluid (CSF) samples from 26 patients with acute ischemic stroke.
Collected CSF specimens longitudinally at day 0–1, day 2–3, day 7–9, 3 weeks, and 3–5 months post-stroke.
CSF-tau increased markedly on day 2–3, peaked at 1 week, and returned to normal baseline concentrations after 3–5 months.
CSF-tau levels correlated strongly with ischemic infarct size (r = 0.95; p < 0.01).
CSF-amyloid beta(1-42) and CSF-apolipoprotein E concentrations demonstrated no significant changes across the post-stroke observation period.

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Implication

Prospective cohort study observes transient surges in cerebrospinal fluid tau correlating with infarct size in acute ischemic stroke patients, indicating that tau marks acute neuronal damage.

Cite This Study

Hesse et al. (2000) studied this question.

synapsesocial.com/papers/6a71fe1de5469ee92be23a3f https://doi.org/10.3233/jad-2000-23-402

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Implication

Prospective cohort study observes transient surges in cerebrospinal fluid tau correlating with infarct size in acute ischemic stroke patients, indicating that tau marks acute neuronal damage.

Cerebrospinal Fluid Markers for Alzheimer's Disease Evaluated after Acute Ischemic Stroke

Key Points

Discussion

Implication

Cite This Study

Cerebrospinal Fluid Markers for Alzheimer's Disease Evaluated after Acute Ischemic Stroke

Key Points

Discussion

Implication

Cite This Study

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