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January 12, 2004Annals of Pharmacotherapy

β-Blocker Underuse in Secondary Prevention of Myocardial Infarction

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Why the study?

Does beta-blocker use improve mortality and reinfarction rates in patients post-myocardial infarction, and what are the barriers to their use?

Population

Patients requiring secondary prevention following a myocardial infarction (MI)

Design

Systematic_review

Authors

MEMatthew J. EverlyHansa Biopharma (Sweden)PHPamela C. HeatonUniversity of ToledoRCRobert J. CluxtonUniversity of Cincinnati Medical Center

Discussion

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Implication

Endorses beta-blockers for post-MI secondary prevention despite comorbidities; confirms Level 1 evidence and prioritizes adherence research.

Structured PICO

Does beta-blocker use improve mortality and reinfarction rates in patients post-myocardial infarction, and what are the barriers to their use?

P
Population
Patients requiring secondary prevention following a myocardial infarction (MI)
I
Intervention
Beta-blockers
O
Outcome
Mortality and reinfarction rateshard clinical

The cardiovascular benefits of beta-blockers for secondary prevention of MI significantly outweigh the risks, even in patients with comorbidities like diabetes, COPD, or peripheral arterial disease.

Cite This Study

Everly et al. (2004) studied this question.

synapsesocial.com/papers/6a71fe79f44fa9f079dfa03dhttps://doi.org/10.1345/aph.1c472
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Beta-Blocker Pooling Project (BBPP): subgroup findings from randomized trials in post infarction patients1988 · 80 citations
  2. 2Diabetic patients and beta-blockers after acute myocardial infarction1990 · 236 citations
  3. 3A Randomized Trial of Propranolol in Patients With Acute Myocardial Infarction1983 · 189 citations
  4. 4The β-Blocker Heart Attack Trial1981 · 233 citations
  5. 5Metoprolol in acute myocardial infarction (MIAMI). A randomised placebo-controlled international trial1985 · 615 citations