What question did this study set out to answer?

To characterize the physiological factors responsible for reduced exercise capacity and abnormal lung function in patients with sickle cell disease.

May 3, 2014American Journal of Hematology

Exercise tolerance, lung function abnormalities, anemia, and cardiothoracic ratio in sickle cell patients

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Authors

EBEduard J. van BeersUtrecht University MPMart N. van der PlasThe University of Sydney ENErfan NurSanquin

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Implication

Observational study reveals that anemia primarily drives reduced exercise capacity in sickle cell disease, indicating that enlarged heart size may restrict lung volumes.

Key Points

To characterize the physiological factors responsible for reduced exercise capacity and abnormal lung function in patients with sickle cell disease.
Evaluated 44 consecutive sickle cell disease patients (27 HbSS, 11 HbSC, and 6 HbS-beta thalassemia; median age 26 years).
Conducted cardiopulmonary exercise testing, pulmonary function tests, chest radiography, and echocardiography.
Peak oxygen uptake was reduced in 83% of patients and correlated with hemoglobin levels (R = 0.440, P = 0.005) and forced vital capacity (R = 0.717, P < 0.0001).
Cardiothoracic ratio on chest radiography was inversely correlated with forced vital capacity (R = -0.637, P < 0.001).
Exercise limitation was predominantly caused by anemia (n = 17) and musculoskeletal impairment (n = 10), with ventilatory or vascular limits occurring rarely.

Cite This Study

Beers et al. (2014) studied this question.

synapsesocial.com/papers/6a71fe90ac440176ef2a7599 https://doi.org/10.1002/ajh.23752

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Implication

Observational study reveals that anemia primarily drives reduced exercise capacity in sickle cell disease, indicating that enlarged heart size may restrict lung volumes.

Exercise tolerance, lung function abnormalities, anemia, and cardiothoracic ratio in sickle cell patients

Discussion

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Implication

Key Points

Cite This Study

Exercise tolerance, lung function abnormalities, anemia, and cardiothoracic ratio in sickle cell patients

Discussion

Member takes

Implication

Key Points

Cite This Study

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