Why the study?
Does injection of a vector carrying TBX18 induce pacemaker activity in a pig model of heart block?
Does injection of a vector carrying TBX18 induce pacemaker activity in a pig model of heart block?
Gene therapy with TBX18 can induce temporary biological pacemaker activity in a preclinical model of heart block.
Supports preclinical TBX18 pacing research; leaves open human translation and safety.
TBX18 is a transcription factor critical to the specification of the sinoatrial node during normal development. A recent pig model of heart block suggests that the injection of a vector carrying TBX18 induces physiologically relevant pacemaker activity for 11 days.
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Michael R. Rosen (2014) studied this question.