Why the study?
Does the 1795insD Na+ channel mutation affect sinoatrial pacemaking and explain bradycardia in LQT3 patients?
Does the 1795insD Na+ channel mutation affect sinoatrial pacemaking and explain bradycardia in LQT3 patients?
Na+ channel mutations displaying a persistent inward current or a negative shift in inactivation may account for the bradycardia and sinus pauses seen in LQT3 patients.
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Supports Na+ channel mutation effects on sinus rate in models; leaves open relevance to bradycardia in LQT3 patients.
Veldkamp et al. (2003) studied this question.
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