Population
HERG potassium channels (wild type and G628C-S631C mutation, with or without MiRP1 coexpression)
Comparison
D-sotalol under various conditions vs Normal extracellular solutions, wild type HERG…
Design
Preclinical
Authors
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Inactivation promotes D-sotalol HERG block in vitro; leaves open whether this mechanism improves antiarrhythmic efficacy or safety in patients.
HERG inactivation stabilizes the interaction between D-sotalol and its receptor during membrane depolarization, providing mechanistic insight into class III antiarrhythmic drug action.
Numaguchi et al. (2000) studied this question.
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