Population
Xenopus oocytes injected with HERG cRNA
Design
Preclinical
Authors
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HERG matches IKr conductance and dofetilide block; supports its role in repolarization but leaves human translation open.
The microscopic physiology and pharmacology of HERG are similar to IKr, supporting the hypothesis that HERG is an important component of the repolarizing cardiac potassium current IKr.
Kiehn et al. (1996) studied this question.
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