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February 5, 2010Circulation Research

Extracellular K + Is a Prerequisite for the Function and Plasma Membrane Stability of HERG Channels

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Population

In vitro models including rabbit ventricular myocytes and human embryonic kidney cells expressing HERG…

Comparison

Low extracellular K+ concentration ([K+]o) vs Normal extracellular K+ concentration (implied)

Design

Preclinical

Authors

HMHamid MassaeliUniversity of OttawaJXJianmin XuQingdao UniversitySZShetuan ZhangQueen's University

Discussion

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Implication

Low K+ may promote LQTS via HERG loss; hypothesis-generating in animal models, human relevance unknown.

Structured PICO

P
Population
In vitro models including rabbit ventricular myocytes and human embryonic kidney (HEK) cells expressing HERG channels
I
Intervention
Low extracellular K+ concentration ([K+]o)
C
Comparator
Normal extracellular K+ concentration (implied)
O
Outcome
HERG channel functional state, internalization, and degradationsurrogate

Low extracellular potassium induces a nonconducting state in HERG channels that triggers their rapid internalization and degradation, providing a mechanistic link between hypokalemia and long QT syndrome.

Cite This Study

Massaeli et al. (2010) studied this question.

synapsesocial.com/papers/6a82b46984489985200f66adhttps://doi.org/10.1161/circresaha.109.215970
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A mutation in the pore region of HERG K+ channels expressed in Xenopus oocytes reduces rectification by shifting the voltage dependence of inactivation1998 · 139 citations
  2. 2Isolation and characterization of IKr in cardiac myocytes by Cs+ permeation2005 · 43 citations
  3. 3Functional interaction between extracellular sodium, potassium and inactivation gating in HERG channels2004 · 7 citations
  4. 4Case 34-19901990 · 897 citations
  5. 5Biochemical and biophysical identification of cystic fibrosis transmembrane conductance regulator chloride channels as components of endocytic clathrin-coated vesicles.1994 · 116 citations