Population
Oocytes expressing HERG potassium channels and an inactivation-deficient mutant HERG channel
Design
Preclinical
Authors
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Clarifies HERG gating in animal models; leaves open translation to human repolarization or arrhythmia risk.
The study elucidates the unique gating properties of HERG potassium channels, showing that the bulk of charge movement is protracted and that inactivation is coupled to activation, which is critical for understanding its role in cardiac repolarization and arrhythmia risk.
Piper et al. (2003) studied this question.
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