Population
hERG (Kv11.1) and Shaker-type voltage-gated potassium channels
Design
Review
Authors
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May refine hERG gating models in arrhythmia research; leaves open experimental validation before any clinical translation.
This review highlights structural and functional differences between hERG and Shaker-type channels that explain the unusually slow activation and deactivation kinetics of hERG channels.
Cheng et al. (2012) studied this question.
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