Population
HERG potassium channels with fluorescent probes attached to three different residues on the NH-terminal end…
Design
Preclinical
Authors
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Offers dual voltage-sensor model for HERG gating; leaves open translation to human cardiac repolarization.
The study proposes a working model with two types of voltage sensor movement to explain the unusual gating properties of HERG potassium channels, which are critical for cardiac action potential repolarization.
Smith et al. (2002) studied this question.
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