Population
Xenopus oocytes expressing mutant hERG channels with single cysteine residues introduced into the S4 region…
Design
Preclinical
Authors
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Supports conserved S4 movement in hERG despite atypical gating; leaves open mechanisms of its unique kinetics.
The extent of S4 transmembrane movement during depolarization in the hERG potassium channel is similar to other Kv channels, despite its unique gating kinetics.
Elliott et al. (2009) studied this question.
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