November 15, 2004The Journal of General PhysiologyOpen Access

Gating Charges in the Activation and Inactivation Processes of the hERG Channel

View Full Paper

Ask AI

Bookmark

Population

hERG channel models

Design

Preclinical

Authors

MZMei ZhangChinese Academy of Social Sciences JLJie LiuThe Affiliated Yongchuan Hospital of Chongqing Medical University GTGea‐Ny TsengVirginia Commonwealth University

Discussion

Member takes

Implication

Outer S4 charges and D466 contribute to hERG activation gating; extends voltage-sensor models but leaves therapeutic translation open.

Structured PICO

Population

hERG channel models

Intervention

Individual mutation of S4's positive charges and D466 to cysteine, and exposure to membrane-impermeable thiol-modifying reagent (MTSET)

Outcome

Effects of mutations on the number of equivalent gating charges transferred during activation (z(a)) and inactivation (z(i)), and state dependence of accessibility of introduced cysteine side chains to MTSETsurrogate

This basic science study reveals that the outer three positive charges in S4 and D466 in S2 contribute to gating charge transfer during hERG activation, while a domain other than S4 is involved in its inactivation process.

Cite This Study

Zhang et al. (2004) studied this question.

synapsesocial.com/papers/6a7e07c1968fa26fcacb5710 https://doi.org/10.1085/jgp.200409119

View Full Paper

Ask AI

Bookmark

Gating Charges in the Activation and Inactivation Processes of the hERG Channel

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Gating Charges in the Activation and Inactivation Processes of the hERG Channel

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider