Population
Xenopus oocytes heterologously expressing human ether-à-go-go-related gene (HERG)
Design
Preclinical
Authors
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Advances IKr channel understanding in animal models; hypothesis-generating for arrhythmia mechanisms and leaves open human translation.
Rapid inactivation from closed states is a significant source of HERG inward rectification, explaining the unique properties of the cardiac I(Kr) current.
Kiehn et al. (1999) studied this question.
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