January 1, 2013Cellular Physiology and BiochemistryOpen Access

Modulation of HERG K⁺ Channels by Chronic Exposure to Activators and Inhibitors of PKA and PKC: Actions Independent of PKA and PKC Phosphorylation

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Structured PICO

Population

HEK293 cells stably expressing HERG

Intervention

Acute and chronic exposure to PKA or PKC activators and inhibitors

Comparator

Control/unexposed cells or cells treated with antioxidants (vitamin E and MnTBAP)

Outcome

HERG channel activity (IHERG density and steady-state activation curve)surrogate

Chronic activation of PKA and PKC impairs HERG channel function through ROS generation rather than direct phosphorylation, suggesting a mechanism for impaired cardiac repolarization in conditions like heart failure.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

May explain repolarization defects via ROS in heart failure models; hypothesis-generating for antioxidant strategies targeting HERG.

Cite This Study

Shu et al. (2013) studied this question.

synapsesocial.com/papers/6a82b25588f77a62c2a0c87d https://doi.org/10.1159/000356616

View Full Paper

Ask AI

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Modulation of HERG K⁺ Channels by Chronic Exposure to Activators and Inhibitors of PKA and PKC: Actions Independent of PKA and PKC Phosphorylation

Structured PICO

Discussion

Implication

Cite This Study

Modulation of HERG K⁺ Channels by Chronic Exposure to Activators and Inhibitors of PKA and PKC: Actions Independent of PKA and PKC Phosphorylation

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider