Population
Stably transfected human embryonic kidney (HEK)293 cells expressing HERG and isolated rabbit cardiac myocytes.
Comparison
Sustained elevation of cAMP by… vs Untreated control or vehicle (DMSO).
Design
Preclinical
Follow-up
Up to 72 hours
Authors
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Remains preclinical; leaves open whether sustained cAMP-PKA signaling modulates HERG in human arrhythmia risk.
Prolonged PKA activity increases HERG channel protein abundance and current density primarily by accelerating the rate of channel synthesis, providing a novel mechanism for channel regulation.
Chen et al. (2009) studied this question.
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