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January 1, 1995British Journal of PharmacologyOpen Access

Potentiation by aminopeptidase P of blood pressure response to bradykinin

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Population

anaesthetized rats

Comparison

apstatin alone or combined with lisinopril vs controls and lisinopril alone

Design

Preclinical

Authors

SKShinichi KitamuraEhime UniversityLCLuis A. CarbiniHenry Ford Health SystemOCOscar A. CarreteroGeneral / Preventive / Lipids

Discussion

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Implication

May warrant investigation of aminopeptidase P inhibition beyond ACE inhibitors; leaves open translation from rat models to clinical use.

Structured PICO

P
Population
anaesthetized rats
I
Intervention
apstatin (aminopeptidase P inhibitor) alone or combined with lisinopril
C
Comparator
controls (for apstatin alone) and lisinopril alone (for combination)
O
Outcome
blood pressure response to bradykinin (maximum response and area under the curve)surrogate

In a rat model, the aminopeptidase P inhibitor apstatin significantly potentiates the vasodepressor response to bradykinin, even in the presence of an ACE inhibitor.

Cite This Study

Kitamura et al. (1995) studied this question.

synapsesocial.com/papers/6a7203dcc2d7c309082726eehttps://doi.org/10.1111/j.1476-5381.1995.tb14897.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of aminopeptidase P inhibition on kinin-mediated vasodepressor responses1999 · 34 citations
  2. 2Apstatin, a selective inhibitor of aminopeptidase P, reduces myocardial infarct size by a kinin‐dependent pathway2001 · 37 citations
  3. 3Excess of Aminopeptidase A in the Brain Elevates Blood Pressure via the Angiotensin II Type 1 and Bradykinin B2 Receptors without Dipsogenic Effect2017 · 2 citations
  4. 4Local Potentiation of Bradykinin-Induced Vasodilation by Converting-Enzyme Inhibition in Isolated Coronary Arteries1992 · 33 citations
  5. 5Effect of bradykinin metabolism inhibitors on evoked hypotension in rats: rank efficacy of enzymes associated with bradykinin‐mediated angioedema2007 · 133 citations