Population
Dahl salt-sensitive rats, salt-resistant spontaneously hypertensive rats, salt-sensitive stroke-prone SHR…
Comparison
High-salt diet vs Low-salt conditions and comparison between…
Design
Preclinical
Authors
Loading...
Identifies salt-dependent QTLs for albuminuria in rats; hypothesis-generating for genetic susceptibility in human hypertensive nephropathy and should not yet change practice.
The SHR genetic background confers greater susceptibility for the development of microangiopathy and tubulointerstitial injury in salt-sensitive hypertension than the SS background.
Siegel et al. (2004) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: