Why the study?
Does atropine compared to glycopyrrolate prolong the impairment of parasympathetic control of heart rate in healthy volunteers?
Does atropine compared to glycopyrrolate prolong the impairment of parasympathetic control of heart rate in healthy volunteers?
Atropine causes a significantly more prolonged impairment of parasympathetic heart rate control compared to equipotent doses of glycopyrrolate, suggesting glycopyrrolate may be preferable for reversing neuromuscular blockade in patients at high cardiovascular risk.
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May favor glycopyrrolate over atropine for neuromuscular reversal in high-risk patients; extends RCT evidence on differential parasympathetic recovery.
Parlow et al. (1997) studied this question.
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