Key result
Healthy men show higher apoA-II and apoC-II, while healthy women exhibit higher apoE.
Cross-Sectional
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The normal levels of apolipoproteins in Japanese were investigated by the single radial immunodiffusion method. No differences were seen between the males and females in the apolipoprotein A-I, B, and C-III levels. However, the levels of apolipoproteins A-II and C-II were higher in the males, while that of apolipoprotein E was higher in the females. These differences were statistically significant. Except for apolipoprotein E, the apolipoprotein levels tended to increase with age more in the females than in the males. The apolipoprotein E level showed a statistically significant positive correlation not only with the total cholesterol level but also with the high density lipoprotein-cholesterol level.
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Goto et al. (1986) conducted a cross-sectional in Normolipidemic healthy state. Sex and age differences (measured by single radial immunodiffusion method) vs. Males vs females across age was evaluated on Normal levels of serum apolipoproteins (A-I, A-II, B, C-II, C-III, and E). Single radial immunodiffusion showed significantly higher apolipoprotein A-II and C-II in males and higher apolipoprotein E in females among healthy Japanese subjects.
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