The effects of indomethacin, a nonsteroidal antiinflammatory agent, on bone ingrowth were studied using a rabbit animal model and a porous cylindrical implant system. Bone ingrowth was found to be independent of pore size in the range tested (0.6-1.0 mm). In the control (placebo-treated) group, there was a significant increase in bone ingrowth between the 2- and 8-week groups of animals. However, in the indomethacin-treated group, there was no increase in bone ingrowth with time.
No takes yet. Share an insight, caveat, or question.
Keller et al. (1989) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: