What question did this study set out to answer?

Synthesize mechanistic evidence explaining how elevated circulating homocysteine induces vascular injury, alters coagulation variables, triggers platelet activation, and promotes thrombosis.

January 1, 2000Seminars in Thrombosis and Hemostasis

Homocysteine, Coagulation, Platelet Function, and Thrombosis

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Synthesize mechanistic evidence explaining how elevated circulating homocysteine induces vascular injury, alters coagulation variables, triggers platelet activation, and promotes thrombosis.
Synthesized findings from human in vivo and in vitro biochemical investigations in patients with homocystinuria due to cystathionine beta-synthase deficiency.
Assessed platelet and coagulation responses following pharmacological interventions, including thrombin inhibition with hirudin and antioxidant therapy with probucol.
Platelet activation in homocystinuric patients remains uncorrected by thrombin inhibition with hirudin but is partially attenuated by the antioxidant probucol.
Homocysteine autooxidation produces reactive oxygen species that induce lipid peroxidation and generate oxidized low-density lipoproteins, driving endothelial dysfunction and platelet activation.
Intracellular accumulation of adenosylhomocysteine suppresses methyltransferase enzymes, preventing normal cellular repair mechanisms in damaged vascular tissue.

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Implication

Review reveals mechanisms of hypercoagulability and platelet activation in hyperhomocysteinemia, indicating oxidative stress drives thrombosis.

Cite This Study

Coppola et al. (2000) studied this question.

synapsesocial.com/papers/6a72090f31a3df824329ed45 https://doi.org/10.1055/s-2000-8469

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Implication

Review reveals mechanisms of hypercoagulability and platelet activation in hyperhomocysteinemia, indicating oxidative stress drives thrombosis.

Homocysteine, Coagulation, Platelet Function, and Thrombosis

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Discussion

Implication

Cite This Study

Homocysteine, Coagulation, Platelet Function, and Thrombosis

Key Points

Discussion

Implication

Cite This Study

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