Why the study?
Does coculture with Schwann cells from normal mice restore contraction in dysgenic murine myotubes?
Does coculture with Schwann cells from normal mice restore contraction in dysgenic murine myotubes?
Coculture with normal Schwann cells restores contraction and ultrastructural organization in dysgenic murine myotubes in vitro.
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Schwann coculture rescues dysgenic myotubes in vitro; hypothesis-generating for glial-muscle interactions and requires in vivo validation before any clinical consideration.
Muscular dysgenesis in mutant mice is characterised by failure of excitation-contraction (E-C) coupling and consequent loss of skeletal muscle contraction. Contractile activity is restored in vitro by the addition of normal mice cells (11) (18) (7). In the present study we show a new model: contraction and ultrastructural organization of dysgenic myotubes are restored by coculture with Schwann cells from normal mice.
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Courbin et al. (1989) studied this question.
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