P159Prognostic value of left atrial functional indices assessed by three dimensional speckle tracking analysis

Background: Left ventricular longitudinal strain (LVLS), Left atrial (LA) volume and functional indices measured by two dimensional echocardiography (2DE) have significant prognostic value for major cardiovascular events (MACE: cardiac death, stroke, nonfatal myocardial infarction and admission for heart failure) in patients with cardiovascular diseases. Prognostic values of left atrial functional indices measured by three-dimensional speckle tracking analysis (3DSTA) were evaluated. Methods: Two hundred eight patients (Male 61%, 65±15yo) with various kind of cardiovascular diseases underwent standard 2DE and 3DSTA of left atrium. Patients with significant mitral valve disease, history of pulmonary vein isolation and persistent atrial fibrillation were excluded. Maximum and minimum left atrial volume (LAVImax and LAVImin), left atrial emptying fraction (LAEmpF), peak global LA area strain (LAAS), circumferential strain (LACS) and longitudinal strain (LALS) were measured using 3DSTA. Standard indices including peak global LVLS (2DLVLS) and left ventricular ejection fraction (LVEF) and LA volume index were also assessed by 2DE. All patients were followed to record MACE. Cutoff line for each index was determined using ROC analysis.