The migration of recirculating autologous and allogeneic lymphocytes through single lymph nodes

Using cannulated single lymph nodes in sheep the migration of 51 Cr‐labeled autologous and allogeneic recirculating lymphocytes (RL) into efferent lymph was studied after i. v. infusion and infusioninto an afferent lymphatic. The majority of autologous and allogeneic RL appeared in efferent lymph 27–36 h after their infusion i. v. and 6–12 h after intralymphatic infusion. The recovery of i. v. infused allogeneic RL in efferent lymph was only 5–10% that of autologous RL. In contrast, there was no difference in the recovery of autologous and allogeneic RL after infusion into an afferent lymphatic. In primed animals the migration of allogeneic RL through a lymph node was completely inhibited.