What question did this study set out to answer?

To investigate whether lipoprotein(a), other plasma lipids, and apolipoprotein(a) size polymorphisms correlate with target-organ damage in patients with arterial hypertension.

June 4, 1997JAMA

Association of Serum Lipoprotein(a) Levels and Apolipoprotein(a) Size Polymorphism With Target-Organ Damage in Arterial Hypertension

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To investigate whether lipoprotein(a), other plasma lipids, and apolipoprotein(a) size polymorphisms correlate with target-organ damage in patients with arterial hypertension.
Assessed serum lipids, apolipoproteins, lipoprotein(a), and target-organ damage staged by World Health Organization guidelines in 277 untreated mild-to-moderate hypertensive patients and 102 healthy controls at a university medical center.
Evaluated apolipoprotein(a) phenotypes and validated results in an independent cohort of 106 hypertensive patients and 105 healthy controls.
Stepwise multivariate analysis identified lipoprotein(a) as the strongest discriminator of target-organ damage (P<.001), exceeding systolic blood pressure (P<.001), hypertension duration (P=.01), and low-density lipoprotein cholesterol (P=.04).
Lipoprotein(a) levels correlated with target-organ damage independently of blood pressure levels, and low-molecular-weight apolipoprotein(a) isoforms were significantly more frequent with increasing severity of organ damage (P=.02).

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Implication

Cross-sectional study finds strong links between lipoprotein(a) levels, low-molecular-weight isoforms, and target-organ damage in hypertensive patients, indicating a genetically driven risk.

Cite This Study

Leonardo A. Sechi (1997) studied this question.

synapsesocial.com/papers/6a720c1f26a7f98052de1b56 https://doi.org/10.1001/jama.1997.03540450045033

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Implication

Cross-sectional study finds strong links between lipoprotein(a) levels, low-molecular-weight isoforms, and target-organ damage in hypertensive patients, indicating a genetically driven risk.

Association of Serum Lipoprotein(a) Levels and Apolipoprotein(a) Size Polymorphism With Target-Organ Damage in Arterial Hypertension

Key Points

Discussion

Implication

Cite This Study

Association of Serum Lipoprotein(a) Levels and Apolipoprotein(a) Size Polymorphism With Target-Organ Damage in Arterial Hypertension

Key Points

Discussion

Implication

Cite This Study

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