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Case series reveals postoperative endophthalmitis linked to contaminated compounded trypan blue, highlighting the need for vigilance regarding compounded drug safety.
We report 6 cases of postsurgical endophthalmitis due to gram-negative bacteria associated with contaminated trypan blue dye from a compounding pharmacy. Unopened trypan blue syringes yielded Pseudomonas aeruginosa and Burkholderia cepacia complex on culture, with pulsed-field gel electrophoresis patterns indistinguishable from patient isolates. Contamination of compounded medications should be considered when investigating outbreaks of postoperative endophthalmitis.
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Sunenshine et al. (2009) studied this question.
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