Apamin reverses atrial arrhythmia inducibility enhanced by nNOS inhibition by mitigating APD abbreviation without altering Ca2+ transients, suggesting posttranslational modification of SK channels.
nNOS inhibition may enhance atrial arrhythmia inducibility via SK channels; hypothesis-generating for AF therapies but should not change practice.
We demonstrated that pharmacological nNOS inhibition increased the atrial arrhythmia inducibility and a specific small-conductance Ca 2+ -activated K + channel blocker, apamin, reversed the enhanced atrial arrhythmia inducibility. Apamin mitigated APD abbreviation without alteration of Ca 2+ transient, implying an underlying mechanism of posttranslational modification of SK channels.
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Koya et al. (2022) studied this question.
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