Using electron spin resonance spectroscopy, we observed that UV radiation (330 nm) increased the endogenous ascorbate free radical concentration in hairless mouse (HRS/J) skin. When the skin was topically treated with a chlorpromazine solution prior to illumination, UV irradiation caused the ascorbate free radical concentration to increase even more. This observation suggests that there is an increased UV‐induced oxidative stress in the presence of chlorpromazine, probably caused by the production of free radicals from chlorpromazine.
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Buettner et al. (1987) studied this question.
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