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May 15, 1988Biochemical JournalOpen Access

Cyclic GMP-dependent protein kinase phosphorylates phospholamban in isolated sarcoplasmic reticulum from cardiac and smooth muscle

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Population

Isolated sarcoplasmic reticulum from cardiac and smooth muscle

Comparison

Cyclic GMP-dependent protein kinase (G-kinase) vs Cyclic AMP-dependent protein kinase (A-kinase)

Design

Preclinical

Authors

LRLuc RaeymaekersUniversity of FerraraFHFranz HofmannUniversity of StuttgartRCR. CasteelsAmerican Heart Association

Discussion

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Implication

Hypothesis-generating in animal models; leaves open translation to human Ca2+ handling therapies.

Structured PICO

P
Population
Isolated sarcoplasmic reticulum from cardiac and smooth muscle
I
Intervention
Cyclic GMP-dependent protein kinase (G-kinase)
C
Comparator
Cyclic AMP-dependent protein kinase (A-kinase)
O
Outcome
Phosphorylation of phospholamban and affinity of the Ca2+ pump for Ca2+surrogate

G-kinase phosphorylates phospholamban in cardiac and smooth muscle sarcoplasmic reticulum, increasing Ca2+ pump affinity in a manner similar to A-kinase.

Cite This Study

Raeymaekers et al. (1988) studied this question.

synapsesocial.com/papers/6a720ca75d37378ac1defc11https://doi.org/10.1042/bj2520269
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sequence analysis of phospholamban. Identification of phosphorylation sites and two major structural domains.1986 · 447 citations
  2. 2Localization of phospholamban in slow but not fast canine skeletal muscle fibers. An immunocytochemical and biochemical study.1986 · 100 citations
  3. 3Concentrations of cyclic AMP-dependent protein kinase subunits in various tissues.1977 · 267 citations
  4. 4Atriopeptin II decreases cytosolic free Ca in cultured vascular smooth muscle cells1986 · 136 citations
  5. 5The Pharmacological and Physiological Role of Cyclic GMP in Vascular Smooth Muscle Relaxation1985 · 680 citations