February 4, 2004AJP Regulatory Integrative and Comparative Physiology

β2-Microglobulin knockout mice treated with anti-asialoGM1 exhibit improved hemodynamics and cardiac contractile function during acute intra-abdominal sepsis

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Population

beta2-microglobulin knockout mice and wild-type mice subjected to cecal ligation and puncture to induce…

Comparison

beta2-microglobulin knockout combined with… vs wild-type mice

Design

Preclinical

Follow-up

18 hours

Authors

WTWeike TaoThe University of Texas Southwestern Medical Center ESEdward R. SherwoodEast Tennessee State University

Discussion

Member takes

Implication

Suggests lymphocyte subsets contribute to sepsis-induced cardiovascular failure; hypothesis-generating and should not change practice.

Structured PICO

Population

beta2-microglobulin knockout mice and wild-type mice subjected to cecal ligation and puncture (CLP) to induce acute intra-abdominal sepsis

Intervention

beta2-microglobulin knockout combined with anti-asialoGM1 treatment

Comparator

wild-type mice

Outcome

Hemodynamics (arterial pressure, heart rate, stroke volume, cardiac output, systemic vascular resistance) and left ventricular contractility at 18 hours after cecal ligation and puncturesurrogate

In a murine model of acute intra-abdominal sepsis, beta2-microglobulin knockout mice treated with anti-asialoGM1 demonstrated preserved hemodynamics and cardiac contractile function compared to wild-type mice.

Cite This Study

Tao et al. (2004) studied this question.

synapsesocial.com/papers/6a720caf75498292b70b4e0d https://doi.org/10.1152/ajpregu.00470.2003

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β2-Microglobulin knockout mice treated with anti-asialoGM1 exhibit improved hemodynamics and cardiac contractile function during acute intra-abdominal sepsis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

β2-Microglobulin knockout mice treated with anti-asialoGM1 exhibit improved hemodynamics and cardiac contractile function during acute intra-abdominal sepsis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider