What question did this study set out to answer?

To determine the distribution and plasticity of TTX-sensitive voltage-gated sodium channels PN1 and Brain III in human sensory neurones and nerves following traumatic injury.

March 1, 2001Neuroreport

Plasticity of TTX-sensitive sodium channels PN1 and Brain III in injured human nerves

View Full Paper

Ask AI

Bookmark

To determine the distribution and plasticity of TTX-sensitive voltage-gated sodium channels PN1 and Brain III in human sensory neurones and nerves following traumatic injury.
Conducted immunohistochemical analysis using specific antibodies on dorsal root ganglia (DRG) from 10 patients with traumatic central axotomy, peripheral nerves from 16 patients with peripheral axotomy, and uninjured control tissues.
PN1 exhibited temporal shifts in sensory cell bodies of injured DRG that matched patterns previously observed for TTX-resistant channels.
Brain III was detected selectively in injured peripheral nerves and was completely absent in uninjured control nerves, control DRG, and DRG following central axotomy.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Histopathological analysis demonstrates distinct plasticity of sodium channels PN1 and Brain III in injured human nerves, suggesting both act as unique targets for novel analgesics.

Cite This Study

Coward et al. (2001) studied this question.

synapsesocial.com/papers/6a720e4931a3df824329f002 https://doi.org/10.1097/00001756-200103050-00014

View Full Paper

Ask AI

Bookmark

Implication

Histopathological analysis demonstrates distinct plasticity of sodium channels PN1 and Brain III in injured human nerves, suggesting both act as unique targets for novel analgesics.

Plasticity of TTX-sensitive sodium channels PN1 and Brain III in injured human nerves

Key Points

Discussion

Implication

Cite This Study

Plasticity of TTX-sensitive sodium channels PN1 and Brain III in injured human nerves

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider