October 12, 2013Journal of Pineal Research

The beneficial effects of melatonin against heart mitochondrial impairment during sepsis: inhibition of iNOS and preservation of nNOS

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Why the study?

Does melatonin improve heart mitochondrial impairment in wild-type and nNOS-deficient mice during sepsis?

Structured PICO

Does melatonin improve heart mitochondrial impairment in wild-type and nNOS-deficient mice during sepsis?

Population

Wild-type and nNOS-deficient mice with sepsis induced by cecal ligation and puncture

Intervention

Melatonin administration

Comparator

Vehicle

Outcome

Changes in mitochondrial oxidative stress and bioenergetics (NOS expression and activity, nitrites, lipid peroxidation, glutathione and glutathione redox enzymes, oxidized proteins, and respiratory chain activity)surrogate

Melatonin protects against sepsis-induced heart mitochondrial impairment by inhibiting iNOS and preserving nNOS, independent of nNOS deficiency.

Discussion

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Implication

Hypothesis-generating for melatonin in sepsis-induced cardiac mitochondrial dysfunction; prospective human studies needed before clinical adoption.

Cite This Study

Ortiz et al. (2013) studied this question.

synapsesocial.com/papers/6a720e8c75498292b70b4f9e https://doi.org/10.1111/jpi.12099

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Implication

Hypothesis-generating for melatonin in sepsis-induced cardiac mitochondrial dysfunction; prospective human studies needed before clinical adoption.

The beneficial effects of melatonin against heart mitochondrial impairment during sepsis: inhibition of iNOS and preservation of nNOS

Structured PICO

Discussion

Implication

Cite This Study

The beneficial effects of melatonin against heart mitochondrial impairment during sepsis: inhibition of iNOS and preservation of nNOS

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider